一项关于青少年自闭症谱系障碍改变白质遗传性的双胞胎研究
John P Hegarty1, Julio C Monterrey1, Qiyuan Tian2
1Stanford University School of Medicine, Stanford, California.
概括
遗传和环境因素影响自闭症谱系障碍 (ASD) 中白质微观结构. 这项对双胞胎的研究揭示了对整体大脑结构的遗传贡献以及与症状严重程度相关的特定路径的环境影响.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 发展心理学 发展心理学
背景情况:
- 白质变化在自闭症谱系障碍 (ASD) 中很常见,但它们的起源仍然不清楚.
- 了解遗传和环境因素的相互作用对于ASD研究至关重要.
研究的目的:
- 研究遗传和环境因素对患有和没有自闭症的双胞胎白质微观结构的影响.
- 量化遗传性和环境对ASD白质变异的贡献.
主要方法:
- 扩散权重的MRI扫描分析了有或没有自闭症的同性双胞胎 (6-15岁) .
- 双胞胎建模评估了影响白质微观结构 (FA和MD) 的附加遗传 (A),共同环境 (C) 和独特环境 (E) 因素.
- 一个新的双胞胎对差异评分分析量化了对特征共变的遗传和环境贡献.
主要成果:
- 总体白质微观结构 (FA和MD) 主要是基因介导的,在控制和ASD一致的双胞胎中.
- 管道特异性分析揭示了影响体FA与认知能力和ASD诊断有关的遗传因素.
- 环境因素,特别是独特的环境因素,影响了投射和关联纤维,与ASD症状严重程度相关.
结论:
- 青少年患有自闭症的白质变化是由遗传倾向和环境影响的结合造成的.
- 遗传因素在整体白质结构中起着重要作用,而环境因素则导致与自闭症症状相关的特定变化.
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