降硫酸盐细菌装入水凝作为长期持久的H2S工厂用于瘤治疗
Yuzhi Qiu1, Man Fan1, Yiqian Wang2
1Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
概括
一种新型的注射水凝装载有硫酸盐减少细菌 (SRB),可可持续地产生硫化 (H2S) 用于瘤治疗. 这种方法抑制瘤生长,并激活全身抗瘤免疫,副作用最小.
科学领域:
- 生物医学工程 生物医学工程
- 癌症治疗 癌症治疗
- 微生物学 微生物学
背景情况:
- 硫化 (H2S) 在癌症治疗中表现有前途,但持续的输送具有挑战性.
- 目前的H2S捐赠剂缺乏耐用性和成本效益,无法广泛临床使用.
研究的目的:
- 开发一种可注射的,自我维持的硫化 (H2S) 生产系统,用于增强瘤治疗.
- 为了利用酸盐降解细菌 (SRB) 封装在氏丁硫酸盐 (ChS) 水凝中作为H2S工厂.
主要方法:
- 制造一种可注射的氏丁硫酸盐 (ChS) 水凝,装有硫酸盐降解细菌 (SRB).
- 在体外评估H2S生产,细菌活力和癌细胞死亡诱导.
- 在瘤模型中对瘤生长抑制,全身免疫反应激活和转移抑制的体内评估.
主要成果:
- 该SRB@ChS凝持续高度H2S的生产超过7天在体外和5天在体内.
- 治疗诱导了瘤细胞中的线粒体损伤和免疫细胞死亡.
- 观察到主要瘤生长的显著抑制,远程和复发性瘤的抑制,以及肺转移的减少.
- 该疗法显示副作用微不足道,并激活了全身抗瘤免疫力.
结论:
- 可注射的SRB@ChS凝为有效的抗瘤治疗提供了一个安全,长期和自给自足的H2S生成平台.
- 这一策略为当前的H2S气体疗法提供了一个有希望的替代方案,增强治疗结果和免疫激活.
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