肺移植接受者的输出管的时间代表了一个务实的终点,以指导预后测试的开发
Andrew T Sage1, John Peel2, Jerome Valero3
1Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
提议将抽管时间作为肺移植预后测试的最佳临床终点. 这一客观措施与患者的治疗结果和医疗保健成本相关,改善了移植中的精准医学.
科学领域:
- 移植医学是一种移植医学.
- 在器官移植中的精密医学.
背景情况:
- 肺移植需要具有明确临床终点的预测性测试.
- 目前缺乏关于肺移植中预后测试最佳终点的共识.
研究的目的:
- 提出并证明"抽出管的时间"是肺移植中预后测试的最佳临床终点.
- 为此目的,评估替代终点的局限性.
主要方法:
- 对肺移植结果的回顾性分析.
- 抽出管的时间 (切断72小时) 和临床结果之间的相关性分析.
- 评估与医疗保健支出的相关性.
主要成果:
- 输出输出时间与初级移植功能障碍3级有很强的相关性.
- 输出管的时间与重症监护室和住院时间长度有关.
- 随着延长的输出时间,观察到医疗费用比率增加了两倍以上.
结论:
- 输出管的时间是肺移植预后测试的临床相关,客观和稳定的终点.
- 这一指标在移植中心之间易于测量,支持其作为首选主要终点的使用.
- 采用抽出管的时间可以提高肺移植中的精密医学应用.
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