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合成和表征n-phosphonium基托及其对冠状病毒病毒杀伤性活动的评估

Celso Fidelis de Moura Junior¹, Deise Ochi¹, Emanuelle Dantas Freitas¹

¹School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Av. Albert Einstein, Campinas 13083-852, Brazil.

International journal of biological macromolecules

|July 5, 2023

概括

一种新型的N-phosphonium chitosan (NPCS) 衍生物显示出对冠状病毒有强大的抗病毒活性. 这种经过修改的多糖有效地抑制低度的病毒传播,细胞毒性最小,为公共卫生应用提供了有前途的解决方案.

科学领域:

材料科学材料科学材料科学
生物化学生化学
病毒学病毒学

背景情况:

全球对有效生物杀伤剂材料的需求急剧增加,特别是在COVID-19大流行之后.
化学修饰多糖类,如奇托提供了一条途径,通过阴离子功能化开发抗病毒药物.

研究的目的:

为了合成和表征N-phosphonium chitosan (NPCS),这是一个四元化基托衍生物.
评估NPCS对冠状病毒 (MHV-3) 的抗病毒疗效和细胞毒性.

主要方法:

奇托桑被化学修饰使用 (4-carboxybutyl) triphenylphosphonium化物产生NPCS具有不同程度的替代.
分析了包括可溶性,热稳定性和泽塔潜力的物理化学性质.
进行了杀菌试验,以确定NPCS对MHV-3的疗效,以及对L929细胞的细胞毒性评估.

主要成果:

在水性和性溶液中,NPCS表现出增强的溶解性,正的泽塔电位与替代程度相关.
所有NPCS变种在0.1 mg/mL度下,在5分钟内实现了99.999%的MHV-3抑制.
在NPCS中,对L929细胞的细胞毒性较低,这表明安全性较好.

结论:

酸 (N-phosphonium chitosan,NPCS) 是一种高效的抗病毒物质,可以对抗冠状病毒.
对于表面涂料和个人防护设备的应用,NPCS是一个有希望的候选者,以减轻病毒传播.
开发NPCS为对抗当前和未来的病毒大流行提供了潜在的好处.

关键词:

抗病毒活性具有抗病毒活性.生物杀伤性材料是生物杀伤性材料.基托桑修饰是一种基托桑修饰.新冠病毒新冠病毒新冠病毒.酸盐是一种酸盐.

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