开发素-石墨烯氧化物混合纳米颗粒用于控制的flurbiprofen输送
Ümit Haydar Erol1, Enes Güncüm2, Nuran Işıklan3
1Department of Chemistry, Faculty of Arts and Sciences, Kırıkkale University, Yahşihan, 71450, Kırıkkale, Turkey; Advanced Technology Application and Research Center, Kilis 7 Aralık University, 79000 Kilis, Turkey.
International journal of biological macromolecules
|July 5, 2023
概括
装有flurbiprofen的奇托桑-石墨烯氧化物纳米颗粒显示了增强的热稳定性和受控的药物释放. 这些生物相容的纳米颗粒是flurbiprofen输送的有希望的药物载体系统.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 自然聚合物纳米粒子 (NPS) 是高效的药物输送系统.
- 弗鲁比 (FB) 是一种非类固醇抗炎药物.
- 控制药物释放对于治疗疗效至关重要.
研究的目的:
- 为了合成和表征flurbiprofen (FB),加载酸盐-石墨烯氧化物 (CS-GO) 混合纳米颗粒 (Nps).
- 评估CS-GO Nps作为FB的受控药物输送系统的潜力.
- 评估GO纳入对纳米粒子特性和FB释放的影响.
主要方法:
- 使用乳液方法合成CS-GO Nps.
- 使用FT-IR,DSC,TGA,XRD,SEM和AFM进行表征.
- 在体外释放药物的研究和细胞毒性评估 (MTT测定).
主要成果:
- 与CS Nps相比,CS-GO Nps表现出增强的热稳定性.
- 颗粒大小在362-718nm之间,负泽塔电位 (-7.67到-27.93mV).
- FB释放表现出两阶段的行为,其中GO的纳入导致了更持续和受控的释放. 发现NPS是生物相容的.
结论:
- CS-GO Nps 是一个有前途的候选人,可以控制flurbiprofen药物输送.
- 加入GO可以改善热稳定性和药物释放特征.
- 合成的纳米粒子显示出良好的生物相容性.
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