高剂量婴儿喷气式干粉吸入器 (DPI) 带有被动循环加载的进步:针对不同的配方进行性能调整
Connor Howe1, Mohammad A M Momin2, Ghali Aladwani1
1Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 W Main Street, PO Box 843015, Richmond, VA 23284, USA.
International journal of pharmaceutics
|July 5, 2023
概括
这项研究开发了一种新的婴儿干粉吸入器 (DPI),具有可调节的计量系统,可有效地将高剂量的气溶输送到婴儿肺部. 该设备确保吸入治疗药物的剂量一致,改善婴儿呼吸系统护理.
科学领域:
- 制药技术 制药技术 制药技术
- 生物医学工程 生物医学工程
- 儿科医学 儿科医学
背景情况:
- 将高剂量的气溶送入婴儿肺部需要专门的设备.
- 现有的干粉吸入器 (DPI) 往往缺乏用于儿科的效率和一致性.
- 需要能够向婴儿提供诸如吸入抗生素,表面活性剂和抗病毒药物等治疗药物的设备.
研究的目的:
- 开发和优化婴儿气喷气DPI的计量系统.
- 为了实现高效和一致的高剂量气溶到婴儿的肺部.
- 调整设备的各种粉末配方,以实现最佳的肺部输送.
主要方法:
- 开发一个含有粉末输送管 (PDT) 和粉末支架的计量系统.
- 采用被动循环加载策略进行多次执行,用户交互最小.
- 修改PDT直径和货架体积,以优化不同配方的肺部输送效率.
- 在使用早产鼻模型进行了体外试验.
主要成果:
- 计量系统在达到稳定状态后,每次启动都显示了一致的剂量管理.
- 对PDT和架子的修改允许对肺部输送效率进行可调节的控制.
- 优化条件导致大约45%的负载剂量传递到肺部.
- 达到每次激活的有限剂量 (<5毫克),适合婴儿使用.
结论:
- 婴儿喷气式DPI具有优化的计量系统,可提供高效和一致的气溶的肺部输送.
- 可调节计量系统可以适应不同的粉末配方,解决了儿科气溶治疗中的一个关键挑战.
- 这项技术有望通过吸入改善对婴儿高剂量治疗药物的管理.
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