通过喷雾干燥进行基于脂质的颗粒工程,以向向肺部输送抗生素
Carolina Corzo1, Djana Crvenjak1, Kamen Sotirov1
1Research Center Pharmaceutical Engineering GmbH, Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology & Biopharmacy, University of Graz, Graz, Austria.
International journal of pharmaceutics
|July 5, 2023
概括
使用基于脂质的微粒的利芬素的肺输送提供了针对性结核病治疗. 这种方法可以提高药物输送到肺巨细胞的速度,减少副作用并提高治疗效果.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 纳米技术 纳米技术
背景情况:
- 结核病的肺部抗生素输送的目标是膜巨细胞中的结核菌菌.
- 这种方法可能会减少与口服/腹腔内服药相关的剂量和严重副作用.
研究的目的:
- 设计含有瑞芬素的脂质微粒,以作为无载体干粉进行吸入.
- 克服用于肺部药物输送的喷雾干燥脂基辅助剂的局限性.
主要方法:
- 喷雾干燥被用于生产脂质微粒,使用贝酸的糖醇全.
- 分析了包括空气动力学直径,几何尺寸和表面电荷在内的粒子特性.
- 在体外细胞毒性和细胞吸收研究中,使用表皮细胞系和膜巨细胞进行了实验.
主要成果:
- 实现了高产量 (83%) 的喷雾干燥,无载体的脂质微粒.
- 颗粒具有可吸入的特性 (MMAD 2.36 微米,GSD 2.05 微米),适合深层肺沉积.
- 报告了高细颗粒物分数 (79.5%) 并没有观察到体外细胞毒性.
- 膜巨细胞的有效体外吸收证实了有针对性的分娩.
结论:
- 通过喷雾干燥,成功设计出完全基于脂质的微粒,用于肺部输送利芬素.
- 工程粒子表现出有利的特征,用于向膜巨细胞的向输送.
- 这种方法突显了喷雾干燥脂基辅料在先进的肺药物递送应用中的潜力.
相关概念视频
Drug Delivery: Miscellaneous Routes
402
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
402
Inhaled Medications
319
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
319


