成年Cynomolgus的球形等价和生物识别参数之间的相关性
Kezhe Chen1, Jian Wu2, Feng Zhao1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.
Experimental eye research
|July 5, 2023
概括
Cynomolgus子的折射和眼部生物特征与人类相似,轴长,角膜半径和角膜厚度具有相似的差异. 这些发现支持它们作为折射误差研究的动物模型的使用.
科学领域:
- 眼科医生 眼科 眼科
- 灵长类动物研究研究
- 比较生物学的比较生物学
背景情况:
- 了解折射误差分布和影响因素对于开发有效干预至关重要.
- 在生物医学研究中,Cynomolgus子越来越多地被用作模型,因此需要对它们的眼睛参数进行表征.
研究的目的:
- 在Cynomolgus子殖民地中描述折射和眼部生物识别参数的分布.
- 分析影响这些非人类灵长类动物折射状态的因素.
主要方法:
- 一项基于人群的横截面研究,涉及263只成年Cynomolgus (520只眼睛).
- 测量包括眼内压力,旋转折射 (球体等价 - SE),角膜曲率半径 (CRC),前腔深度 (ACD),透镜厚度 (LT),轴长 (AL),中央角膜厚度 (CCT) 和胸膜厚度 (ChT).
- 多重回归分析被用来确定折射和眼部生物识别之间的关联.
主要成果:
- 折射误差的患病率:29.42%的超视, 27.12%的输出眼, 33.27%的轻度至中度近视, 10.19%的高近视. 平均SE为-1.27 ± 3.44 D. 这一值为 -1.27 ± 3.44 D.
- 主要生物识别发现:平均AL为18.76±0.89毫米,平均CRC为5.70±0.22毫米,平均CCT为454.30±32.40微米,平均CHT为188.96±38.19微米.
- 轴长 (AL) 单独解释了SE变异的40.5%;年龄,AL和CRC一起解释了57.5%.
结论:
- 在Cynomolgus子的折射特性和眼部生物量学与人类非常相似.
- 轴长,角膜曲率半径和胸膜厚度表现出与人类相似的变化模式.
- 具有自然发生的折射误差的Cynomolgus子代表了研究折射发育和干预的有价值的动物模型.
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