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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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细胞衰老在末角质病变中的影响

Mohammad Soleimani1, Seyed Mahbod Baharnoori1, Kasra Cheraqpour2

  • 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Experimental eye research
|July 5, 2023
PubMed
概括

子暴露会导致角膜中的细胞衰老,导致晚发子角质病变. 向衰老可能为角膜损伤和纤维化提供新的治疗方法.

关键词:
衰老的衰老 衰老的衰老这是一种Beta-galactosidase.末气是什么意思?末气是什么意思?末角膜病变是一种末角膜病变.酸盐末是一种末.眼睛表面的表面是眼睛的表面.衰老是一种衰老.

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科学领域:

  • 眼科医生 眼科 眼科
  • 毒理学 毒理学 毒理学
  • 细胞生物学 细胞生物学

背景情况:

  • 末剂是化学战的水囊剂,会造成眼睛表面的重大损伤.
  • 末角膜病变 (MK) 呈现为角膜模糊,和新血管,可能导致视力丧失.
  • 新出现的证据表明,细胞衰老在末引起的伤害和受损的伤口愈合中起着作用.

研究的目的:

  • 建立第一个推迟发作的末角质病变 (MK) 的小鼠模型.
  • 为了研究酸在角膜中诱导细胞衰老的作用.
  • 评估衰老标志物与角膜纤维化之间的相关性.

主要方法:

  • 开发了一种使用末的推迟发作的MK的小鼠模型.
  • 在角膜细胞中通过beta-galactosidase染色评估衰老的病理迹象.
  • 量化了beta-galactosidase染色与角膜纤维化之间的关系.

主要成果:

  • 酸暴露导致角膜细胞中的细胞衰老.
  • 在beta-galactosidase染色和角膜纤维化程度之间观察到显著的相关性.
  • 衰老似乎是慢性和晚期发作的眼睛表面损伤的潜在机制.

结论:

  • 酸暴露会诱导角膜细胞衰老,有助于延迟发病的MK.
  • 细胞衰老是子诱导的角膜损伤的一个关键病理机制.
  • 抗衰老疗法有望加速角膜愈合并减少MK患者的纤维化.