在慢性淋巴细胞白血病中使用共价BTK抑制剂后使用皮尔托布鲁丁尼布
Anthony R Mato1, Jennifer A Woyach1, Jennifer R Brown1
1From Memorial Sloan Kettering Cancer Center (A.R.M.), and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center (N.L.), New York, the Donald and Barbara Zucker School of Medicine, Northwell-Hofstra, Uniondale (J.M.R.), Northwell Health Cancer Institute at Lake Success, North New Hyde Park (J.M.R.), and the Lymphoma Section, Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo (F.H.-I.) - all in New York; the Ohio State University Comprehensive Cancer Center, Columbus (J.A.W.), and Cleveland Clinic, Cleveland (D.J.) - both in Ohio; Dana-Farber Cancer Institute and Harvard Medical School - both in Boston (J.R.B.); Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan (P.G.), and IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli" (P.L.Z.), and Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università di Bologna (P.L.Z.), Bologna - all in Italy; the Center for Blood Disorders and Cellular Therapy, Swedish Cancer Institute (K.P.), and the Fred Hutchinson Cancer Center, University of Washington (C.S.U.) - both in Seattle; Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Centre, Oxford (T.A.E.), and the Department of Haematology, St. James's University Hospital, Leeds (T.M.) - both in the United Kingdom; the Institute of Hematology and Transfusion Medicine, Warsaw (E.L.-M.), and Maria Sklodowska-Curie National Research Institute of Oncology, Krakow (W.J.) - both in Poland; Peter MacCallum Cancer Centre, Royal Melbourne Hospital and the University of Melbourne, Melbourne, VIC (C.S.T., J.F.S.), and Linear Clinical Research and Sir Charles Gairdner Hospital (C.Y.C.), and the Medical School, University of Western Australia (C.Y.C.), Perth, WA - all in Australia; Medical College of Wisconsin, Milwaukee (N.N.S.); University of North Carolina at Chapel Hill, Chapel Hill (C.C.C.); the University of California, San Francisco, San Francisco (B.F.); Florida Cancer Specialists, Sarah Cannon Research Institute, Sarasota (M.R.P.), and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami (A.J.A.) - both in Florida; Winship Cancer Institute, Emory University, Atlanta (J.B.C.); the Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia (J.N.G.); Sarah Cannon Research Institute, Nashville (I.W.F.); Robert H. Lurie Comprehensive Cancer Center, Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago (S.M.); Loxo@Lilly (M.B., B.N., P.A., D.W., D.E.T.) and Eli Lilly (C.W., A.S.R.) - both in Indianapolis; and M.D. Anderson Cancer Center, Houston (W.G.W.).
皮尔托布鲁丁尼在治疗慢性淋巴细胞白血病 (CLL) 和小淋巴细胞淋巴瘤 (SLL) 之后显著有效.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性淋巴细胞白血病 (CLL) 和小淋巴细胞淋巴瘤 (SLL) 患者在联合布鲁顿氨酸激酶 (BTK) 抑制剂治疗失败后经常面临糟糕的结果.
- 在复发性或耐火性B细胞恶性瘤中,急需新的治疗策略.
研究的目的:
- 评估非共价BTK抑制剂皮尔托布鲁丁尼的疗效和安全性,在以前用BTK抑制剂治疗的CLL或SLL患者中.
- 评估与皮尔托布鲁丁尼布治疗相关的整体应答率,无进展生存率和不良事件.
主要方法:
- 进行了一项1-2期临床试验,涉及与皮尔托布鲁丁尼布治疗的复发或耐药B细胞癌症患者.
- 通过对整体反应进行独立审查来评估有效性,并将无进展的生存率和安全性作为次要终点.
主要成果:
- 在247名接受过BTK抑制剂的重度预治疗的CLL/SLL患者中,Pirtobrutinib实现了73.3%的整体应答率.
- 无进展生存时间的中位数为19.6个月,可管理的不良事件包括感染 (71.0%) 和出血 (42.6%).
- 导致停止治疗的与治疗相关的不良事件很低 (2.8%).
结论:
- 皮尔托布鲁丁尼在重度预治疗的CLL/SLL患者中表现出显著的疗效,这些患者之前接受了共价BTK抑制剂治疗.
- 安全性概况的特点是常见的不良事件,如感染,出血和中性质减退,治疗中止率低.
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