动物的多样性和包容性:动物伦理委员会如何帮助改进翻译?
1Philosophy, University at Albany, State University of New York, Albany, New York, USA mpiotrowska@albany.edu.
Journal of medical ethics
|July 5, 2023
概括
临床前研究往往无法转化为人类群体,导致动物研究被浪费. 动物伦理委员会可以通过解决研究中不充分的代表性来改善药物翻译.
科学领域:
- 生物医学研究的研究.
- 翻译科学是翻译的科学.
- 动物研究伦理 动物研究伦理
背景情况:
- 临床前发现的可转化到人类群体存在重大危机.
- 目前的动物模型表明人类药物安全性和有效性的预测价值较低.
- 临床试验中药物失败率高表明动物研究中普遍存在的徒劳性,导致动物遭受痛苦而没有相应的人类益处.
研究的目的:
- 解决临床前研究中翻译失败的危机.
- 突出动物伦理委员会在提高研究翻译性方面的作用.
- 为加强对动物研究的科学和伦理审查提出解决方案.
主要方法:
- 分析生物医学研究中翻译失败的原因.
- 检查动物研究中代表性不足的伦理和科学影响.
- 审查动物伦理委员会的权威和原则.
主要成果:
- 在临床前研究中代表性不足是导致翻译失败的一个关键因素.
- 动物试验在预测人类结果方面的成功率很低.
- 伦理审查委员会有权减轻翻译失败的问题.
结论:
- 动物伦理委员会可以在解决翻译危机方面发挥至关重要的作用.
- 在审查委员会内重新优先考虑现有的伦理原则,可以解决代表性不足的问题.
- 提高临床前研究的可翻译性将减少动物的痛苦,并提高人类患者的益处.
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