在卵子授精中,对精子形态的新修改标准可以减少ICSI的发生率,而不会影响试管婴儿的结果
Tseng-Kai Lin1, Leng-Lai Chan2, Tsung-Hsuan Lai3
1Lin Tseng-Kai Babymake Clinic, Hsinchu, Taiwan; Division of Infertility, Department of Obstetrics and Gynecology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
Taiwanese journal of obstetrics & gynecology
|July 5, 2023
概括
与正常精子患者相比,患有不太严重的精子化症 (LST) 的患者可以使用常规授精实现类似的试管婴儿成功率. 这表明LST患者可能不需要细胞内质精子注射 (ICSI),这可能会降低试管婴儿费用.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 精子形态分析 精子形态分析
背景情况:
- 内细胞质精子注射 (ICSI) 经常用于男性因子不孕症,包括精子.
- 较不严重的三精子症 (LST) 是通过特定的精子形态和运动标准来定义的.
- 在LST患者中评估传统授精结果可以为治疗策略提供信息,并减少不必要的ICSI使用.
研究的目的:
- 使用常规授精,比较LST患者和正常精子患者之间的试管婴儿结果.
- 确定LST是否需要ICSI,或者传统授精是否是一个可行的替代方案.
- 潜在地降低LST患者在IVF中的ICSI率.
主要方法:
- 对330名接受常规试管婴儿授精的患者进行了回顾性研究.
- 在LST组的76名患者与正常精子组的254名患者的比较.
- 评估关键的试管婴儿参数:受精,胚胎质量,植入,怀孕和活产率.
主要成果:
- 在LST和正常精子组之间的受精率,胚胎质量,植入率或临床怀孕率方面没有观察到统计学上显著的差异.
- 活产率 (28.9%对26.7%) 和堕胎率 (9.6%对10.2%) 在两组之间是可比的.
- 这些发现是正确的,无论LST定义中的精子形态学参数如何.
结论:
- 传统授精是接受试管婴儿的LST患者的成功方法.
- LST患者可能不需要ICSI,因为受精和随后的试管婴儿结果不会受到显著影响.
- 这项研究支持重新考虑LST的ICSI,可能提供更具成本效益的试管婴儿方法.
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