在因COVID-19疾病住院的患者中,高尿血和不良结果
Itamar Feldman1, Ayman Natsheh2, Gabriel S Breuer2,3
1Department of Internal Medicine, Rheumatology Unit, Shaare Zedek Medical Center feldman.itamar@mail.huji.ac.il.
Clinical medicine & research
|July 5, 2023
概括
住院COVID-19患者的高尿酸水平表明死亡率和严重结果的风险更高. 这项研究表明,高尿素血可能作为不良事件的预后标志物.
科学领域:
- 医学研究 医学研究
- 临床医学 临床医学
- 传染性疾病 传染性疾病
背景情况:
- 高尿路血症与死亡风险和严重的COVID-19有关.
- 了解高尿血在COVID-19预后中的作用至关重要.
研究的目的:
- 调查超尿血症作为COVID-19患者死亡率和不良结果的风险因素.
- 评估尿酸水平与COVID-19严重程度之间的关联.
主要方法:
- 对1566名住院COVID-19患者的回顾性审查 (2020年3月至11月).
- 在入院时分析可用的尿酸 (UA) 水平.
- 幸存者与非幸存者之间的UA水平的比较,以及与疾病严重程度的相关性.
主要成果:
- 21.2%的患者患有高尿血 (UA>7 mg/dL).
- 较高的入院UA水平与死亡率的增加相关 (P < 0.05).
- 高尿路血与强化氧气支持和更长的住院时间有关 (P < 0.05).
结论:
- 尿酸水平升高与住院COVID-19患者的不良结果有关.
- 高尿路血症可能会整合基线风险和急性因素,如炎症和功能衰竭.
- 需要进一步评估作为预后标记的高尿素血症.
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