基因型通过环境相互作用和异种性影响了卡塔丁羊的寄生虫耐药性的表达
Brian C Arisman1, Joan M Burke2, James L M Morgan3
1Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Journal of animal science
|July 5, 2023
概括
卡塔丁羊对胃肠道寄生虫具有遗传耐药性,具有显著的基因型,环境相互作用影响了寄生虫耐药性特征. 考虑到这些因素,可以提高育种计划的有效性.
科学领域:
- 动物遗传学动物遗传学
- 寄生虫学的寄生虫学
- 绵羊生产 绵羊生产
背景情况:
- 抗虫药物的有效性降低需要使用替代的寄生虫控制策略.
- 绵羊生产者越来越多地选择具有对胃肠道寄生虫固有的耐药性的品种.
- 卡塔丁羊是具有抗寄生虫能力的显著品种,在美国多样化的环境中养.
研究的目的:
- 通过环境相互作用 (G×E) 来研究 Katahdin 绵羊中的寄生虫耐药性特征的基因型.
- 为了确定在不同生态管理集群中存在异构复杂性.
- 评估环境因素对寄生虫耐药性繁殖的影响.
主要方法:
- 从9个生态管理集群中收集了3,527只卡塔丁羔羊的体重 (BW),FAMACHA分数 (FAM) 和便卵数 (FEC).
- 使用了三种动物模型,包括固定和随机效应,包括生态管理集群.
- 估计遗传性,遗传相关性,并使用生态管理集群相互作用的 sire 评估 G×E.
主要成果:
- 遗传概率估计为BW的0.36±0.07,FEC的0.31±0.07,FAM的0.26±0.05.
- 在BW和FEC (-0.26±0.08) 和FAM (-0.16±0.08) 之间观察到有利的遗传相关性.
- 对FEC和FAM检测到显著的遗传和表型异种性;G×E解释了12-20%的表型变异.
结论:
- 基因型通过环境相互作用和异种性显著影响卡塔丁羊的寄生虫耐药性特征.
- 将G×E和异种性纳入育种计划对于提高选择效率至关重要.
- 解决这些复杂问题可以优化育种策略,以提高绵羊生产中的寄生虫抵抗力.
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