在患有渐进和稳定的轻度认知障碍的患者中,白质高强度轨迹
Farooq Kamal1, Cassandra Morrison2, Josefina Maranzano2
1From the Department of Psychiatry (F.K., Y.Z., M.D.), McGill University; Douglas Mental Health University Institute (F.K., Y.Z., M.D.); Department of Neurology and Neurosurgery (C.M., J.M.), Faculty of Medicine, and McConnell Brain Imaging Centre (C.M.), Montreal Neurological Institute, McGill University; and Department of Anatomy (J.M.), University of Quebec in Trois-Rivières, Canada. farooq.kamal@mail.mcgill.ca.
Neurology
|July 5, 2023
概括
随着时间的推移,白质过强度 (WMH) 在轻度认知障碍 (MCI) 患者中随着时间的推移而增加,而不论粉样蛋白状况如何. 这种积累与痴呆症转化有关,特别是在粉样蛋白阳性个体中.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年病的医生 老年病的医生
背景情况:
- 白质超强度 (WMH) 是与认知衰退相关的与年龄相关的大脑变化.
- 需要进一步调查WMH负担,粉样蛋白阳性和痴呆症转化为轻度认知障碍 (MCI) 之间的关系.
研究的目的:
- 研究MCI患者的WMH负担如何随着时间的推移而变化,区分粉样蛋白阴性 (Aβ-) 和粉样蛋白阳性 (Aβ+) 组.
- 为了比较稳定的MCI患者的WMH进展与那些在两个粉样蛋白状态内转换为痴呆症的人.
主要方法:
- 利用了来自阿尔茨海默病神经成像计划的数据,包括患有MCI的参与者,APOE ɛ4状态和可用的粉样蛋白测量.
- 分析了820名参与者 (55-90岁) 的纵向数据,分为四组:Aβ+进展者,Aβ-进展者,Aβ+稳定者和Aβ-稳定者.
- 采用线性混合效应模型来研究总体和区域WMH负担的差异,平均每位参与者 (长达13年) 获得5.7个随访点.
主要成果:
- 在大多数地区,Aβ-稳定个体与Aβ+进展者和Aβ+稳定群体相比,具有较低的基线WMH.
- 与Aβ-稳定组相比,所有组都表现出加速WMH积累.
- Aβ+进展者显示,随着时间的推移,WMH负担的增长最为显著.
结论:
- 在患有MCI的个体中,WMH积累是痴呆症转化的一个重要因素,不管他们的粉样蛋白β状况如何.
- 这些发现强调了WMH进展在导致老年人痴呆的神经退行过程中的作用.
更多相关视频
相关概念视频
01:26Alzheimer's Disease: Overview
527
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
527
01:30Cognitive Development During Adulthood
160
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
160
01:30Dementia
141
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
141
01:22Alzheimer's Disease: Treatment
220
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
220