慢性淋巴细胞白血病患者的感染
Mariana Guarana1, Marcio Nucci2
1Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Hematology, transfusion and cell therapy
|July 5, 2023
概括
感染是慢性淋巴细胞白血病 (CLL) 患者的重大风险,随着治疗而演变. 向治疗引入了诸如真菌感染之类的新风险,需要谨慎管理.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 感染是慢性淋巴细胞白血病 (CLL) 患者的主要并发症.
- 新诊断的CLL患者面临着Streptococcus pneumoniae和Haemophilus influenzae等封装细菌的高风险.
研究的目的:
- 审查CLL患者感染的流行病学.
- 考虑各种治疗方案对感染风险的影响.
- 在CLL中简要讨论感染管理策略.
主要方法:
- 关于CLL感染流行病学的文献综述.
- 基于治疗方案的感染谱分析.
- 讨论针对性治疗的新出现的感染风险.
主要成果:
- 随着治疗的开始和疾病的进展,感染谱变得更广泛.
- 累积免疫抑制会增加多种治疗线的感染风险.
- 向疗法,如布鲁顿激酶抑制剂,增加了侵入性真菌病的发生率,特别是阿斯伯吉洛症.
结论:
- 在CLL中感染流行病学是动态的,并受到治疗的影响.
- 了解治疗特异性风险对于管理CLL患者至关重要.
- 积极管理感染,包括真菌病,对于改善患者的治疗结果至关重要.
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