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产前诊断食道 - 性能和后果
T Arntzen1, A Mikkelsen2, R Emblem1
1Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Pediatric Surgery, Oslo University Hospital, Oslo, Norway.
Journal of pediatric surgery
|July 5, 2023
概括
随着时间的推移,食道缩 (EA) 的产前诊断增加,识别出更复杂的病例. 虽然使得早期的外科护理,产前诊断与更长的住院时间和EA患者的呼吸机时间相关.
科学领域:
- 医学研究 医学研究
- 儿科外科手术 儿科外科手术
- 新生儿科学 新生儿科学
背景情况:
- 产前诊断先天性形通常被认为是有利的.
- 在10-40%的病例中,食道 (EA) 在产前检测到.
- 影响EA检测率和结果的因素需要进一步调查.
研究的目的:
- 评估影响食道缩 (EA) 产前检测率的因素.
- 为了比较EA患者的产前诊断和没有产前诊断的结果.
- 在两个不同的时间段分析EA诊断和管理的趋势.
主要方法:
- 一项对136名EA患者的回顾性研究,分为两个组:1996-2002年 (n=68) 和2014-2020年 (n=68).
- 从电子病历中提取了临床变量,包括产前症状和产前/产后结果.
- 使用统计分析,包括赔率比率和多变量分析,以确定有意义的关联.
主要成果:
- 产前EA诊断率显著增加,从9% (1996-2002) 增加到28% (2014-2020).
- EA类型A/B和相关异常与更高的产前诊断可能性有关.
- 产前诊断的患者经历了更早的手术单位到来,但在医院停留时间和呼吸机时间更长,产前诊断预测了停留时间.
结论:
- 产前诊断的EA病例往往涉及更复杂的形 (A/B型) 和相关异常,导致新生儿发病率增加.
- 尽管有潜在的好处,如早期手术访问,产前诊断对EA患者的整体影响需要进一步研究.
- 该研究强调需要批判性地评估产前诊断在EA管理中的后果.
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