系统的整合会诱导多个记忆系统,以实现在男性小鼠观察性恐惧记忆中的灵活回忆策略
Joseph I Terranova1,2, Jun Yokose1, Hisayuki Osanai1
1Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Nature communications
|July 5, 2023
概括
小鼠在自己的环境中回忆起最近的观察性恐惧记忆,但在观察者和演示者环境中回忆起远程记忆. 这涉及不同的大脑区域,如背部海马和中间前额叶皮层 (mPFC).
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 记忆研究 记忆研究
背景情况:
- 观察上下文恐惧条件化 (CFC) 允许从他人那里学习恐惧.
- 在观测CFC中对视角依赖的记忆回忆的神经基础是未知的.
研究的目的:
- 在观测CFC中研究近期与远程记忆回忆的神经机制.
- 确定从观察者与演示者的角度回忆记忆中的大脑电路.
主要方法:
- 使用雄性小鼠进行观测CFC实验.
- 用行为测试来评估不同背景下的记忆回忆.
- 使用神经活动映射和电路追踪技术.
主要成果:
- 最近的观察CFC记忆回忆对观察者来说是具体的.
- 远程记忆回忆发生在观察者和演示者环境中.
- 背部海马中介的近期记忆回忆;mPFC-basolateral杏仁体通路中介的远程回忆.
结论:
- 观察CFC记忆回忆策略是灵活的,并且取决于上下文.
- 神经回路的功能重组是记忆持久性和回忆视角的基础.
- 不同的mPFC亚群调节远程记忆中的不同视角的回忆.
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