在怀孕前短暂的掠食风险会影响孩子和孙子
Sriya Bhattacharya1,2, Phillip E MacCallum1, Mrunal Dayma3
1Department of Psychology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
Scientific reports
|July 5, 2023
概括
在受孕前的父母掠食者压力会诱导多代 (F1和F2) 后代的焦虑类行为和过度兴奋. 这种跨代的可塑性凸显了创伤事件的长期生理和行为影响.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 遗传学 是一个遗传学.
背景情况:
- 创伤事件会影响后代的生理和行为.
- 跨代可塑性描述了没有直接遗传突变的特征的继承.
研究的目的:
- 调查预孕前掠食者压力对后代 (F1和F2) 的影响.
- 为了确定父母的压力暴露是否影响后代的焦虑类行为和生理反应.
主要方法:
- 在受孕之前,小鼠被暴露在捕食者压力 (活老鼠) 或对照条件下.
- 评估了后代 (F1和F2) 的行为和生理学 (海马cFOS,皮质).
- 交叉培养研究被用来区分父母的压力影响与母亲的环境影响.
主要成果:
- 怀孕前的压力导致F1后代的焦虑行为和过度兴奋增加.
- F1后代表现出海马神经元活动和葡萄糖皮质体系统功能的改变.
- 在F2后代中观察到行为变化,表明持续的跨代效应.
- 交叉培养证实了怀孕前的压力,而不是母亲的环境,确定了后代的表型.
结论:
- 短暂的预先概念捕食者压力可以在多代人中引起持久的行为和生理变化.
- 应对压力的跨代可塑性是理解适应和遗传的一个重要因素.
- 这些发现表明,可怕事件的多代影响可能在野生种群中很常见.
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