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Updated: Jul 24, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

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内分子相互作用动态调节由人类和小鼠α-synuclein所产生的纤维形成

Takashi Ohgita1, Hiroki Kono2, Izumi Morita3

  • 1Laboratory of Biophysical Chemistry, Kyoto Pharmaceutical University, 5 Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto, 607-8414, Japan. ohgita@mb.kyoto-phu.ac.jp.

Scientific reports
|July 5, 2023
PubMed
概括

小鼠的α-synuclein (αS) 比人类的αS更快地形成粉样纤维. 在小鼠αS中,一种特定的S87N替代物通过破坏分子内相互作用来加速纤维细胞的形成,从而提供治疗洞察力.

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