试图建模白质衰老和认知衰退背后的因果结构
Jan Willem Koten1,2, Karl Koschutnig3,4, Guilherme Wood3,5
1Brain Imaging Facility of the Interdisciplinary Centre for Clinical Research of the University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074, Aachen, Germany. jan.koten@uni-graz.at.
Scientific reports
|July 5, 2023
概括
年龄独立地影响白质完整性和认知能力. 然而,一些大脑纤维的恶化,特别是在半球之间,可能源于与年龄相关的认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 衰老研究研究 衰老研究
背景情况:
- 了解衰老,大脑结构和认知功能之间的关系对于解决与年龄相关的认知衰退至关重要.
- 以前的研究表明,这些因素之间存在复杂的相互作用,但确切的机制仍在争论中.
研究的目的:
- 用先进的神经成像技术研究年龄,白质完整性和认知功能之间的相互作用.
- 测试竞争的神经认知衰老模型,以确定这些因素如何随着时间的推移相互影响.
主要方法:
- 扩散张力成像 (DTI) 用于评估整个大脑的白质完整性.
- 使用Voxel-wise结构方程建模 (SEM) 来分析神经成像数据中的关系.
- 艾卡伊克信息标准 (AIC) 用于在竞争假设中进行模型选择.
主要成果:
- 评估了神经认知衰老的两个主要模型:独立因子模型和认知调解模型.
- 独立因子模型,假定年龄对白质和认知的单独影响,与大约60%的voxels一致.
- 认知调解模型,暗示认知调解年龄与白质关系,得到16%的声音的支持,特别是在半球间白质道中.
结论:
- 虽然年龄主要独立地影响白质完整性和认知,但与年龄相关的白质变化的子集,特别是连接纤维,可能是由认知功能下降驱动的.
- 这些发现突出了老化大脑中的双向影响,并提出了旨在维护认知和结构完整性的干预措施的潜在目标.
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