评估接受糖尿病黄斑瘤常规抗VEGF治疗的患者对布罗卢西祖马布的初始反应:一项回顾性,单中心的观察性研究
Takao Hirano1, Akane Kumazaki2, Ryuji Tomihara2
1Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. takaoh@shinshu-u.ac.jp.
Scientific reports
|July 5, 2023
概括
切换为brolucizumab (IVBr) 糖尿病黄斑 (DME) 显著减少中央黄斑厚度和黄斑体积没有不良事件. 布罗卢齐祖马布作为DME患者的替代疗法具有前景.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 抗血管内皮生长因子 (VEGF) 疗法是DME的标准治疗方法.
- 对于现有的抗VEGF药物,患者的反应和剂量间隔可能具有挑战性.
研究的目的:
- 评估DME患者内内勃鲁西祖马布 (IVBr) 的初始疗效和安全性,这些患者先前接受过常规抗VEGF药物治疗.
- 在切换到IVBr后,评估视觉敏度,视网膜厚度和黄斑体积的变化.
主要方法:
- 对20名DME患者的23只眼睛进行了回顾性观察性研究,后者转换为IVBr.
- 在传统抗VEGF和IVBr治疗之前和之后评估的最佳校正视力敏度 (BCVA),中央黄斑厚度 (CMT) 和黄斑体积 (MV).
- 评估眼内炎症 (IOI) 和前腔炎症.
主要成果:
- 在传统的抗VEGF和IVBr疗法后,BCVA显著改善.
- 与基线和常规治疗相比,切换到IVBr后,CMT和MV显著下降.
- 在IVBr治疗后没有观察到IOI或前腔腔发烧的显著变化.
结论:
- 静脉内勃鲁西祖马布有效地减少了DME患者的黄斑胀和体积.
- 转换为IVBr显示出良好的安全性,没有观察到眼内炎症.
- 布罗卢齐祖马布代表了对DME患者的潜在替代治疗方法,这些患者对现有的抗VEGF疗法没有反应或不耐受.
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