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在西班牙裔人口中对癌症相关血栓栓塞的三个预测模型进行比较
Allan Ramos-Esquivel1,2, Ana Marenco-Flores3, Gabriel Hernández-Romero4
1Medical Oncology Department, Hospital San Juan de Dios. Caja Costarricense de Seguro Social, San José, Costa Rica. allan.ramos@ucr.ac.cr.
Journal of thrombosis and thrombolysis
|July 5, 2023
概括
在西班牙裔癌症患者中,静脉血栓塞栓症 (VTE) 的预测得分显示中等准确度. 虽然Khorana,PROTECHT和CONKO得分可以识别高风险个体,但它们预测静脉瘤事件的整体能力仍然有限.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 静脉血栓塞栓症 (VTE) 是癌症患者的一个重大并发症.
- 准确的风险预测对于接受化疗的门诊癌症患者的预防策略至关重要.
研究的目的:
- 为了评估和比较Khorana,PROTECHT和CONKO得分在预测有固体瘤的门诊西班牙裔患者中VTE的表现.
主要方法:
- 研究了一组708名在外诊的西班牙裔患者,新诊断出固体瘤,接受化疗.
- 在治疗开始时计算了Khorana,PROTECHT和CONKO得分.
- 六个月累计的VTE发病率使用Fine & Gray竞争风险模型进行估计.
- 接收器操作特征 (ROC) 曲线分析评估了预测性能 (c-统计,灵敏度,特异性).
主要成果:
- 六个月后累计VTE发生率为4.45%.
- 通过所有三个评分 (Khorana,PROTECHT,CONKO) 确定的高风险患者与低风险患者相比,VTE的风险明显更高 (HRs从2.66到3.68).
- 对于ROC曲线的c-统计分别为0.62,0.62和0.65对于Khorana,PROTECHT和CONKO分数,这表明整体歧视性表现不佳.
结论:
- 科拉纳,PROTECHT和CONKO得分可以对西班牙裔癌症患者的静脉瘤风险进行分类.
- 然而,这些评分的总体预测性能,用于识别所有患有血栓栓塞事件风险的患者是有限的.
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