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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
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A living cell's primary tasks of obtaining, transforming, and using energy to do work may seem simple. However, the second law of thermodynamics explains why these tasks are harder than they appear. None of the energy transfers in the universe are completely efficient. In every energy transfer, some amount of energy is lost in a form that is unusable. In most cases, this form is heat energy. Thermodynamically, heat energy is defined as the energy transferred from one system to another that...
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The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
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Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
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一个最小细胞的进化

R Z Moger-Reischer1, J I Glass2, K S Wise2

  • 1Department of Biology, Indiana University, Bloomington, IN, USA.

Nature
|July 5, 2023
PubMed
概括

尽管最初的适应性成本很低,但工程最小的细胞迅速发展到与更大的对手的性能相匹配和超越. 自然选择迅速提高了这些简化的生物的适应性.

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科学领域:

  • 合成生物学
  • 进化生物学
  • 微生物学

背景情况:

  • 只有基本基因的最小细胞, 提供了对生命基本过程的洞察力.
  • 了解简化生物的进化动态对于各种应用至关重要.

研究的目的:

  • 为了比较工程最小细胞与其非最小细胞的进化轨迹.
  • 研究基因组最小化对突变率,适应性和适应性的影响.

主要方法:

  • 合成最小细胞和Mycoplasma mycoides之间的比较进化实验.
  • 监测突变率,健康状况,生长速度和细胞大小超过2000代.
  • 对遗传点和表观效应的分析,特别是ftsZ中的突变.

主要成果:

  • 最小的细胞表现出高突变率,与其他细菌相比,不受基因组大小的影响.
  • 在2000代内恢复了最小细胞的初始适应性减少.
  • 最小的细胞在相对适应性方面比非最小的细胞进化速度快39%.
  • 由于ftsZ突变,不同于非最小细胞的显著增加,最小细胞的细胞大小进化受到限制.

结论:

  • 自然选择迅速提高工程最小细胞的适应性.
  • 基因组简化带来了进化挑战和约束,特别是在细胞形态方面.
  • 对最小细胞进化的洞察力有助于理解内共生体,生物技术底盘和合成细胞的改进.