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Updated: Jul 24, 2025

Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay
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Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay

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基于大数据集的化学毒性回归模型对Vibrio fischeri的化学毒性

Xinliang Yu1, Minghui He2, Limin Su3

  • 1Hunan Provincial Key Laboratory of Environmental Catalysis and Waste Regeneration, College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, 411104, Hunan, People's Republic of China. yxl@hnie.edu.cn.

Archives of environmental contamination and toxicology
|July 5, 2023
PubMed
概括

使用随机森林的新型全球定量结构-毒性/活性关系 (QSAR) 模型准确预测了1236种化学物质的Vibrio fischeri毒性. 该模型实现了高预测准确度,与现有的本地模型相美.

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Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
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Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
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One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
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Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
184