炎症性肠道疾病患者的SARS-CoV-2感染:第一个和第二次大流行浪潮之间的比较
Cristina Bezzio1, Marta Vernero2, Stefania Costa2,3
1Gastroenterology Unit, Rho Hospital, ASST Rhodense, Corso Europa 250, 20017, Rho, MI, Italy. bezzioc@gmail.com.
患有炎症性肠病 (IBD) 和SARS-CoV-2感染的患者在意大利的第一波和第二波COVID-19大流行之间经历了不同的结果. 第一个浪潮看到老年患者有更多的并发症和显著更高的严重结局,包括死亡率.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 2020年,意大利经历了两次主要的SARS-CoV-2浪潮.
- 炎症性肠病 (IBD) 患者在流行病期间代表了一个脆弱的人群.
- 在流行病浪潮之间比较IBD患者的结果对于了解疾病影响至关重要.
研究的目的:
- 为了比较意大利第一和第二波大流行期间感染SARS-CoV-2的IBD患者的特征和结果.
- 在COVID-19流行病的不同阶段,确定影响IBD患者疾病严重程度和结果的因素.
主要方法:
- 进行了一项纵向观察性研究.
- 937名被诊断患有SARS-CoV-2感染的IBD患者被纳入.
- 根据第一波 (2020年3月至5月) 或第二波 (2020年9月至12月) 感染情况,患者被分为两组.
主要成果:
- 第一波的患者年龄较大,患性结肠炎和并发症的可能性更高,居住在意大利北部.
- 波之间没有观察到性别或IBD活动的显著差异.
- 与第二波相比,第一波与肺炎,住院,呼吸系统支持和死亡率显著增加有关.
结论:
- 感染SARS-CoV-2的IBD患者的人口,临床和地理特征在第一波和第二波大流行期间有所不同.
- 感染SARS-CoV-2的IBD患者的结果在第一波期间更糟糕.
- 流行病学情况和诊断能力的差异可能影响了患者特征和结果的观察变化.
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