在早产婴儿中出现周周内出血的危险因素:倾向性得分匹配分析
Jinglan Huang1,2, Yan Wang1,2,3, Tian Tian4
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
BMC pediatrics
|July 5, 2023
概括
电解质失衡,败血症,血小板低,机械呼吸增加了早产婴儿脑出血 (PV-IVH) 的风险. 这些因素也会加剧PV-IVH的严重程度,而不依赖于妊娠年龄.
科学领域:
- 新生儿科学 新生儿科学
- 儿科神经学 儿科神经学
- 关键护理医学 关键护理医学
背景情况:
- 周腹腔内腔出血 (PV-IVH) 是早产婴儿的一个重大问题.
- 虽然较年轻的妊娠年龄 (GA) 是已知的危险因素,但对PV-IVH严重性的其他因素需要进一步调查.
研究的目的:
- 在早产婴儿 (不到28周的GA) 中识别PV-IVH的发展和严重性的风险因素,独立于妊娠年龄.
- 分析特定临床条件与PV-IVH发病率和严重程度的关联.
主要方法:
- 对早产婴儿 (2009-2020年) 进行了回顾性病例对照研究,通过头骨超声波诊断出PV-IVH.
- 倾向性得分匹配用于对比组 (没有PV-IVH与PV-IVH;轻度PV-IVH与重度PV-IVH) 的妊娠年龄进行控制.
- 多变量逻辑回归确定了独立的风险因素.
主要成果:
- PV-IVH的发病率为55.6%,轻度和重度病例分别为28.7%和26.9%.
- PV-IVH的独立风险因素包括电解质障碍,早期发作的败血症,血小板缺血,侵入性机械通风和男性性别.
- 电解质障碍,血小板减少和侵入性机械通风独立地与严重的PV-IVH相关.
结论:
- 电解质障碍,早期发作的败血症,血小板减少,侵入性机械通风和男性性别是早产婴儿PV-IVH的重要危险因素,无论妊娠年龄如何.
- 这些因素也会导致PV-IVH的严重程度.
- 识别和管理这些风险因素可能有助于预测和潜在地预防PV-IVH及其严重形式在脆弱的早产婴儿.
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