喘患者的维生素D受体和维生素D结合蛋白基因多态:试点研究
Daina Bastyte1,2, Laura Tamasauskiene3,4, Ieva Golubickaite5
1Department of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, Lithuania. daina.bastyte@lsmu.lt.
BMC pulmonary medicine
|July 5, 2023
概括
维生素D受体 (VDR) 和维生素D结合蛋白 (VDBP) 基因变异与喘有关. 特定的VDR和VDBP多态性与喘患者的维生素D水平,乙酸细胞数量和IgE水平相关.
科学领域:
- 遗传学和免疫学 遗传学和免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 维生素D的作用是由维生素D受体 (VDR) 和维生素D结合蛋白 (VDBP) 介导的.
- 在VDR或VDBP的遗传变异 (多态) 可能会影响维生素D水平,并影响喘和形发育.
研究的目的:
- 与健康对照组相比,研究VDR和VDBP基因单核酸多态 (SNPs),25-氧维生素D (25(OH) D水平,血液中乙酸氨基细胞计数和喘患者的IgE总水平之间的关联.
主要方法:
- 一项涉及63名喘患者和32名健康受试者的病例控制研究.
- 通过皮肤刺伤测试评估过敏原敏感性;通过螺旋计评估肺功能.
- 使用标准测定法 (ELISA) 测量血液中乙酸氨基细胞数量,血清25(OH) D和总IgE水平.
- 使用TaqMan SNP基因定型试验分析的VDR和VDBP基因多态性.
主要成果:
- VDR rs11168293的G基因基因在患有维生素D缺乏症 (<20 ng/ml) 的喘患者中更为普遍,并且与血液中异氨基酸细胞数量较高有关.
- VDBP rs7041的A等位基因与过敏性喘患者的IgE总水平显著上升有关.
结论:
- 在VDBP和VDR基因中的多态性,特别是rs11168293 G等位基因和rs7041 A等位基因,与喘中的25(OH) D水平,血液中阳性素和总IgE有关.
- 这些发现表明,维生素D,VDR和VDBP基因多态性在喘的发病过程中起作用,不论喘状态如何.
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