血清度的影响,以及对爱尔兰卫生系统死亡率的影响修饰剂
Conor Walsh1, Leonard D Browne1,2, Robert Gilligan3
1School of Medicine, University of Limerick, Limerick, Ireland.
BMC nephrology
|July 5, 2023
概括
异常的血清水平 (失血症) 会增加住院患者的死亡风险. 这种风险受年龄,功能和临床环境的影响,具体值因这些因素而异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 血清水平的异常 (缺血血症) 与住院患者的死亡率增加有关.
- 年龄,功能和临床环境等因素对这种关联的影响需要进一步调查.
研究的目的:
- 调查失血症对爱尔兰卫生系统内总和因特定原因死亡率的影响.
- 探索年龄,功能和临床环境如何改变血清水平和死亡率之间的关系.
主要方法:
- 来自国家病监测系统的32,666名参与者的回顾性队列研究.
- 低血症定义为血清<135 mmol/L;高血症定义为>145 mmol/L.
- 用多变量Cox比例危险回归和处罚线模型来分析死亡风险.
主要成果:
- 在8.5%的患者中存在失能血症,与U形死亡风险相关.
- 低血和高血都显著增加了心血管,恶性和非心血管/非恶性死亡的风险.
- 年龄,功能和临床环境显著改变了与死亡率的关系,风险值各不相同.
结论:
- 在正常范围之外的血清水平对死亡率产生不利影响,并与特定的死亡原因有关.
- 与失血症相关的死亡风险的门因年龄,功能和临床环境而异.
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