相关实验视频
Updated: Jul 24, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
492
沉重吸烟对患有食道癌的患者非编码RNA表达的影响
Qin Wen1, Xinlan Mao1, Xinling Shi1
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
BMC medical genomics
|July 5, 2023
概括
沉重的吸烟通过改变非编码RNA (ncRNA) 表达,显著恶化食道癌的存活率. 基于这些与吸烟相关的ncRNAs的新风险评分预测了不良预后,并表明烟草通过ncRNA机制抑制瘤免疫力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 吸烟是已知的食道癌的危险因素,但其分子机制尚未完全理解.
- 非编码RNAs (ncRNAs) 在食道癌中具有预后价值,但吸烟特定的ncRNA表达模式未被描述.
- 这项研究调查了大量吸烟对食道癌患者的ncRNA表达的影响.
研究的目的:
- 综合评估大量吸烟对食道癌的危害.
- 描述与吸烟相关的非编码RNA (ncRNA) 表达模式.
- 构建与吸烟相关的RNA调控网络,并确定预后生物标志物.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据库用于转录组和临床数据.
- 使用考克斯回归和差异表达分析 (edgeR) 来识别与吸烟相关的ncRNA.
- 构建RNA调节网络并进行途径丰富分析 (GO,KEGG).
主要成果:
- 严重吸烟与整体存活率差 (HR: 3.167) 有关.
- 在吸烟和非吸烟群体之间确定了195个差异表达的lncRNA和73个miRNA.
- 发展出与吸烟相关的预后风险得分,与生存率差和免疫细胞透改变有关.
结论:
- 吸烟在食道癌中显著影响ncRNA表达,影响预后.
- 一个基于ncRNA的新型风险评分有效预测患者的结果.
- 在食道癌中,吸烟可能通过ncRNA介导的机制抑制瘤免疫力.
相关概念视频
lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
Esophageal Strictures-I: Introduction
153
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
153
Barrett Esophagus-II: Clinical Manifestations and Management
214
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
214

