老化的卵巢损害了急性中风的结果
Taylor E Branyan1,2, Jocelyn Aleksa1, Esteban Lepe1
1Department of Neuroscience and Experimental Therapeutics, Women's Health in Neuroscience Program, Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center College of Medicine, 8447 Riverside Pkwy, Bryan, TX, 77807, USA.
Journal of neuroinflammation
|July 5, 2023
概括
在老年雌性大鼠中,切除卵巢改善了中风的结果,这与预期相反. 这表明老化的卵巢可能会通过释放炎症性免疫细胞来加剧中风的严重程度.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生殖生物学 生殖生物学
背景情况:
- 卵巢激素通常被认为是针对成年女性中风的神经保护作用.
- 生殖衰老 (RS) 的女性比正常骑自行车的女性表现出更糟糕的中风结果.
- 老化卵巢在中风后果中的作用,特别是在RS女性中,仍然不清楚.
研究的目的:
- 为了研究卵巢切除术 (OVX) 对中年,生殖老化 (RS) 的雌性大鼠中风结局的影响.
- 探索RS大鼠中风后卵巢和大脑的免疫变化.
- 为了确定老化的卵巢是否会加剧中风的严重程度.
主要方法:
- 中脑动脉封闭 (MCAo) 模型的中风在成年OVX和卵巢完整的RS大鼠.
- 评估中风后的感觉运动功能和心脏病发作量.
- 卵巢和大脑中免疫细胞群 (T细胞,Tregs,M2巨细胞) 的流细胞计分析.
主要成果:
- 与卵巢完整的RS大鼠相比,OVXRS大鼠表现出明显更好的感觉运动功能和减少了心脏病发作量.
- 衰老的卵巢在中风后显示炎症性细胞因子减少和免疫细胞概况改变 (Tregs,M2巨细胞增加).
- OVX RS大鼠在大脑中显示Tregs和M2类巨细胞的增加,与更好的中风预后相关.
结论:
- 与年轻女性卵巢激素的神经保护作用相反,RS女性的卵巢衰老似乎加剧了中风的严重程度.
- 脑卒中后卵巢居民免疫细胞的消耗,以及OVX大鼠大脑中的抗炎细胞的增加,表明老化卵巢的有害作用.
- 这些发现强调了需要考虑雌性动物中风后老化卵巢的免疫变化.
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