区域性大脑预测阿尔茨海默氏症疾病频谱中的日常功能下降
Mark A Dubbelman1,2, Kayden J Mimmack3, Emily H Sprague4
1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. mdubbelman@bwh.harvard.edu.
Alzheimer's research & therapy
|July 5, 2023
概括
难以完成日常任务可能是早期阿尔茨海默病 (AD) 的信号. 大脑中较高的陶积累与日常功能下降的更快的相关性,特别是在有症状的个体中.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 日常生活工具活动 (IADL) 的困难可能是阿尔茨海默病 (AD) 的早期指标.
- 了解认知衰退和大脑病理之间的关系对于早期AD检测至关重要.
研究的目的:
- 调查日常功能变化与阿尔茨海默病 (AD) 临床谱中脑负担之间的关联.
- 要确定tau负担或粉样β是否是AD功能衰退的更强有力的预测因素.
主要方法:
- 利用了阿尔茨海默病神经成像计划 (ADNI) 581名参与者的数据.
- 使用功能活动问卷 (FAQ) 评估日常功能中的纵向变化.
- 分析了基线图定子发射断层扫描 (PET) 负担在关键大脑区域和常见问题的得分变化之间的关系,调整为粉样蛋白-β.
主要成果:
- 额头,部和部区域的负荷增加与日常功能下降的速度更快有关.
- 这种关联即使经过对全球皮质粉样蛋白-β进行调整后仍然显著.
- 和功能衰退之间的关系在认知症状的个体中比认知正常的个体更明显.
结论:
- 在特定的大脑区域的基线tau负担是日常功能纵向下降的重要预测因素,特别是在具有认知症状的个体中.
- 陶病理似乎与AD早期的功能衰退更密切相关,而不是阿米洛伊德-β病理.
- 在发生痴呆症的人群中进行进一步的纵向研究是有必要的,以阐明AD病理和随着时间的推移而发生的功能变化之间的动态相互作用.
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