口腔微生物组衍生签名使喉癌的非侵入性诊断成为可能
Shuting Yu1, Junru Chen2, Yan Zhao3
1Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Dongcheng District, Beijing, China.
Journal of translational medicine
|July 5, 2023
概括
口腔冲洗微生物组分析可以诊断喉状细胞癌 (LSCC). 这项研究在口腔冲洗中确定了特定的细菌种群,在区分LSCC患者和对照者方面达到85.7%的准确性,突出了潜在的非侵入性生物标志物.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 头癌,包括喉状细胞癌 (LSCC),与改变的微生物群有关.
- 有限的数据存在于LSCC患者的特定口腔微生物组.
- 口腔微生物群作为LSCC早期诊断生物标志物的潜力在很大程度上仍未被探索.
研究的目的:
- 为了描述LSCC患者的口腔微生物组.
- 为了识别与LSCC相关的细菌种群.
- 使用口腔微生物群开发LSCC的诊断分类器.
主要方法:
- 16S rRNA基因测序用于分析口腔冲洗和组织样本.
- 从77名LSCC患者和76名有声息肉的对照患者收集了样本.
- 生物信息分析确定了与临床病理特征相关的微生物分类组.
主要成果:
- 在LSCC患者和对照人群之间观察到细菌属丰度的显著差异.
- 使用口腔冲洗微生物群特征开发了一个预测分类器.
- 该分类器在诊断LSCC时实现了85.7%的准确性.
结论:
- 这项研究提供了第一个使用口腔冲洗微生物组分类特征用于LSCC诊断的证据.
- 口腔冲洗微生物组代表了LSCC的潜在的非侵入性生物标志物.
- 口服冲洗微生物组的变异为对LSCC的临床洞察提供了一个新的来源.
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