尿液CXCL10用于评估经过移植后的BK多瘤病毒复制
Jana Haller1, Matthias Diebold1, Karoline Leuzinger2,3
1Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
Transplantation
|July 6, 2023
概括
尿液中的CXCL10水平随着BKPyV的重新激活阶段而增加. 低尿量CXCL10可靠地排除诱细胞和BKPyVDNAemia,有助于监测脏全移植健康.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 尿液CXCL10是脏全移植炎症的生物标志物.
- 炎症可能源于排斥,感染或BK多重瘤病毒 (BKPyV) 复制.
- 在移植接受者中,BKPyV是一个重大问题.
研究的目的:
- 为了比较BKPyV重新激活的不同阶段的尿液CXCL10水平.
- 评估尿液CXCL10作为脏移植患者BKPyV复制的生物标志物.
主要方法:
- 在一项随机试验中,分析了235名患者的763个尿样.
- 查尿液CXCL10水平的样本,并进行完整的尿液沉积物分析.
- 尿液诱细胞分析在尿液收集后±3天内进行;前30天内没有排斥发作.
主要成果:
- 尿液中的CXCL10水平从2.31 ng/mmol (没有BKPyV) 升至4.35 ng/mmol (BKPyV病毒病) 和16.42 ng/mmol (存在诱细胞).
- 观察到的最高水平 (中位数为42.59 ng/mmol) 是BKPyV DNAemia.
- 尿液CXCL10在检测BKPyVDNAemia方面表现出高精度 (AUC0.882),NPV为99%,为3ng/mmol.
结论:
- 尿液中CXCL10水平在BKPyV病毒病期间显著升高,特别是在诱细胞脱落和BKPyVDNAemia时.
- 尿液中CXCL10的低值 (<3 ng/mmol) 提供了很高的确定性,可以排除诱细胞和BKPyVDNAemia.
- 尿液CXCL10是一种有价值的非侵入性生物标志物,用于监测移植后的BKPyV活性.
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