两合一的聚合物无捐赠者原药中等精度和协同性前列腺癌治疗
Bingbing Zhao1, Yuqing Wan1, Xiang Zhou1
1Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 211198, China.
ACS applied materials & interfaces
|July 6, 2023
概括
这项研究引入了一种新型的双重作用纳米前药物,用于对抗割抵抗性前列腺癌 (CRPC). 这种创新的药物输送系统有效降低了雄激素受体水平,并增强了化疗,提供了一个有前途的新疗法策略.
科学领域:
- 生物医学工程 生物医学工程
- 纳米医学是一种纳米医学.
- 在瘤学瘤学.
背景情况:
- 化疗在治疗前列腺癌 (PCa) 方面面临挑战,特别是由于耐药性和副作用的原因,抗割PCa (CRPC) 面临挑战.
- 目前的治疗方法往往难以克服抵抗机制并减轻严重的不良事件.
研究的目的:
- 开发一种新的二合一纳米原药 (T-NO/E2-PMs),用于增强CRPC疗法.
- 抑制雄激素受体 (AR) 表达和重编程瘤微环境.
- 为了改善雌二醇介导的低氧CRPC治疗.
主要方法:
- 炸弹 (BBN) 装饰的纳米颗粒封装了氧化 (NO) 供体和17β-雌二醇 (E2).
- 在体外和体内研究来评估纳米原药的疗效.
- 评估AR降低调节,瘤微环境调节和化疗敏感化.
主要成果:
- 有效的细胞内部化通过BBN介导的内细胞分裂.
- 控制释放NO和E2作为对细胞内刺激的反应.
- 显著下调AR水平,扭转CRPC特征.
- 提高雌醇的化疗敏感性,促进PCa细胞亡并抑制转移.
结论:
- 这种T-NO/E2-PMs纳米原药显示出对CRPC有强大的治疗效果.
- 这种双重行动战略为先进的纳米医学开发提供了一个有前途的平台.
- 这种方法通过向AR并改善化疗敏感性,有效地提高了治疗效果.
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