利尿剂量是等待心脏移植的门诊患者的强烈预后因素
Guillaume Baudry1, Guillaume Coutance2, Richard Dorent3
1Université de Lorraine, Centre d'Investigations Cliniques Plurithématique 1433, INSERM DCAC, CHRU de Nancy, F-CRIN INI-CRCT, Reicatra, Vandoeuvre-lès-Nancy, 54500, France.
ESC heart failure
|July 6, 2023
概括
在等待心脏移植 (HT) 的晚期心力衰竭患者中,高剂量循环利尿剂预测结果会更差. 高剂量与增加的死亡率和紧急的HT有关,有助于风险分层.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 循环利尿剂的剂量对于管理晚期心力衰竭至关重要.
- 在等待心脏移植 (HT) 的门诊患者中高剂量循环利尿剂的预后影响仍然不清楚.
研究的目的:
- 为了评估HT等候名单上的患者不同循环利尿剂的预后价值.
主要方法:
- 一组700名在等待HT的门诊患者被按循环性尿剂剂量 (低,中,高) 分类.
- 主要结局是等候名单死亡或紧急HT的复合.
- 经过对临床和生化混因素进行调整后的统计分析.
主要成果:
- 较高的利尿剂量与增加的N-终端亲B型性利尿素,肌素和肺压力相关.
- 在高剂量组 (25.6%) 与低剂量组 (7.4%) 相比,12个月死亡或紧急HT的风险明显更高.
- 高剂量利尿剂独立预测增加等候名单死亡率或紧急HT (aHR 2.23) 和死亡 (aHR 6.18).
结论:
- 高剂量的循环利尿剂与残留拥堵有关,并预测HT前患者的结果不佳.
- 这种随时可用的变量可以帮助等待心脏移植的患者进行风险分层.
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