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同时刺激AGE和LPS通过PLCγ1/JNK/NF-κB通路在MC3T3-E1细胞中诱导炎症介质

Natsuko Tanabe1,2, Keiko Tomita3, Soichiro Manaka2,3

  • 1Department of Biochemistry, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan.

Cells
|July 6, 2023
PubMed
概括

先进的糖化最终产品 (AGEs) 与脂多糖化物 (LPS) 结合,增加骨质母细胞中的炎症介质. 这一过程涉及脂酶Cγ1 (PLCγ1) 和c-Jun N-终端激酶 (JNK) 的激活,导致核因子-kappa B (NF-κB) 转位.

关键词:
年龄的 AGEs.在IL-1α上.在JNK中,JNK就是JNK.在LPS中使用LPS.在 NF-κBB 中.在PGE2的基础上,PGE2在 PLCγ1γ1 中.在S100A9A9中使用.

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