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口腔腔干细胞用于骨再生的潜力:一个范围审查

Josefa Alarcón-Apablaza^1,2, Ruth Prieto³, Mariana Rojas⁴

¹Research Centre in Dental Sciences (CICO-UFRO), Dental School, Universidad de La Frontera, Temuco 4780000, Chile.

|July 6, 2023

概括

来自口腔的介酶体 stromal 细胞 (MSC) 显示出对骨再生的前景. 各种口服MSC来源,当与支架相结合时,可以有效地修复小型和大型骨缺陷,风险最小.

科学领域:

再生医学是一种再生医学.
口腔和牙面部外科手术
生物材料科学生物材料科学

背景情况:

由于创伤,手术或先天性问题导致的骨缺陷带来了重大的临床挑战.
口腔是一个易于获取和丰富的介质细胞 stromal 细胞 (MSCs) 的来源,具有被证明的骨质生成潜力.
了解不同口服MSC来源的比较疗效对于优化骨再生策略至关重要.

研究的目的:

进行范围审查,分析和比较从口腔中获取的介质细胞 (MSCs) 的骨再生应用潜力.
识别和分类用于骨缺陷修复的各种类型的口服MSC.
评估这些MSC在临床前和临床环境中的有效性和安全性.

主要方法:

根据PRISMA-ScR指南进行了全面的范围审查.
在主要的科学数据库中进行了搜索:PubMed,SCOPUS,SciELO和Web of Science.
调查使用口腔衍生干细胞促进骨再生的研究也被纳入了分析.

主要成果:

在726项初步研究中,27项被选中进行详细审查.
识别的MSC来源包括牙髓干细胞 (永久性和炎症性),脱皮的树叶牙干细胞,牙周带干细胞,培养的自身骨周细胞,口腔脂肪衍生的细胞和自身骨衍生的MSC.
在使用牙周带和牙髓干细胞的小缺陷中观察到成功的骨形成,在使用骨,骨和口腔脂肪衍生的干细胞的较大缺陷中,经常与支架结合使用.

结论:

口腔衍生中细胞 (MSCs) 是治疗大面骨缺陷的有前途的治疗方案.
将MSC与适当的支架相结合,对于有效的输送和增强骨再生至关重要.
进一步的研究可能会完善脚手架设计和MSC选择,以改善面骨重建的临床结果.

关键词:

骨再生骨再生干细胞是干细胞的组成部分.耳鼻神经系统耳鼻神经系统组织工程是组织工程.

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