一个洞察PI3k/Akt路径和相关的蛋白质-蛋白质相互作用在代谢综合征:最近的更新
Kanika Verma1, Ritika Jaiswal1, Sarvesh Paliwal1
1Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Journal of cellular biochemistry
|July 6, 2023
概括
PI3K/Akt路径及其蛋白相互作用在糖尿病等代谢疾病中至关重要. 了解这些相互作用可能会导致代谢综合征的新疗法.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 生理学 生理学 生理学
背景情况:
- 氨酸/氨酸-蛋白激酶B (Akt) 是PI3K/Akt路径的关键组成部分,有三种异型 (Akt1,Akt2,Akt3).
- Akt1和Akt2对于细胞存活和葡萄糖平衡至关重要,这种途径与高血压,脂质失调和糖尿病等代谢疾病有关.
研究的目的:
- 审查PI3K/Akt途径在代谢综合征 (MS) 中的作用.
- 在MS的背景下,突出涉及Akt的蛋白质-蛋白质相互作用的意义.
- 为了确定MS管理的潜在治疗目标.
主要方法:
- 文献综述侧重于PI3K/Akt路径.
- 涉及Akt,FOXO1和mTOR的蛋白质与蛋白质相互作用的分析.
- 检查该途径与代谢疾病的关联.
主要成果:
- PI3K/Akt路径从根本上参与了代谢综合征的发展和进展.
- 特定的蛋白质与蛋白质相互作用,例如与FOXO1和mTOR的相互作用,对于途径调节至关重要.
- 这些相互作用的失调有助于MS的病理生理学.
结论:
- PI3K/Akt路径及其相互作用的蛋白质是代谢调节和疾病的核心.
- 在这种途径中准特定的蛋白质-蛋白质相互作用为开发新型多发性硬化疗法提供了有希望的战略.
- 对这些相互作用的进一步调查可以指导开发代谢综合征的有效管理策略.
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
3.7K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.7K
The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Insulin: The Receptor and Signaling Pathways
1.3K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.3K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
cAMP-dependent Protein Kinase Pathways
6.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.4K


