叶酸补充的演变 - 从适合所有人的一个尺寸到个性化的,精确的,多路径的发展
Qiangqiang He1,2, Jianping Li3
1Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong Province, China.
Journal of translational internal medicine
|July 6, 2023
概括
叶酸对健康至关重要. 维生素D3增强了叶酸的生物可用性和同氨酸的清除,为个性化的叶酸补充策略铺平了道路,以优化健康结果.
科学领域:
- 营养生物化学和分子生物学.
- 代谢调节和营养相互作用.
背景情况:
- 叶酸对生理功能至关重要;低水平增加心血管疾病和神经管缺陷的风险.
- 叶酸是一种常见的补充剂,需要代谢转化,影响生物可用性.
- 5甲基四基叶酸在单碳代谢中提供直接利用,其运输受到SLC19A1基因变异的影响.
研究的目的:
- 探索酸盐 (维生素D3) 在提高叶酸的生物可用性和同型半氨酸清除中的作用.
- 讨论SLC19A1基因变异对叶酸代谢的影响.
- 为了突出个人化叶酸补充剂 (3P) 的新兴趋势.
主要方法:
- 审查最近的生物医学,队列研究和临床试验.
- 分析与叶酸运输和同型半氨酸代谢相关的基因表达变化.
- 研究酸对降低叶酸载体 (RFC) 和囊氨酸β-合成酶的影响.
主要成果:
- 酸补充剂显著增加了RFC和cystathionineβ-synthase的表达.
- 这表明酸可以增强叶酸的生物可用性,并协同帮助同型半氨酸的清除.
- 该SLC19A1基因变异影响叶酸状态,强调个体代谢差异.
结论:
- 酸在优化叶酸的生物可用性和同型半氨酸代谢方面发挥着关键作用.
- 了解个体遗传变异和营养相互作用对于有效的叶酸补充至关重要.
- 叶酸补充的未来正在转向个性化,精确,多路径 (3Ps) 方法,以最大限度地提高益处并最大限度地降低风险.
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