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在胃肠道疾病中神经神经刺激的治疗潜力和机制

Ximeng Wang¹, Jiande Dz Chen²

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21228, USA.

Journal of translational internal medicine

|July 6, 2023

概括

圣神经刺激 (SNS) 通过改善关压力和直肠感觉,有效治疗便失禁. 然而,它对便秘无效,需要进一步研究刺激性肠综合征 (IBS) 和炎症性肠病 (IBD) 的应用.

科学领域:

胃肠病学胃肠病学
神经调节是一种神经调节.
消化系统疾病消化系统疾病

背景情况:

圣神经刺激 (SNS) 是一种神经调节技术,在治疗某些胃肠道疾病方面具有成熟的应用.
新兴的研究探索了它对更广泛条件的潜力,需要对当前证据进行全面审查.

研究的目的:

系统地审查神经神经刺激 (SNS) 在各种胃肠道疾病中的临床应用和潜在机制.
评估SNS在便失禁,便秘,刺激性肠综合征 (IBS),炎症性肠病 (IBD) 和上胃肠运动障碍方面的疗效和局限性.

主要方法:

在PubMed和Web of Science上进行了系统的文献搜索,以寻找特定胃肠道疾病中SNS的研究.
纳入标准侧重于系统性审查,元分析和与每个疾病相关的随机对照试验.
来自相关研究的发现被汇集,总结和批判性地讨论.

主要成果:

SNS是用于便失禁的高效疗法,其已证明的机制包括增加关节压力和改善直肠感觉.
目前的证据表明,SNS对便秘无效,需要进行方法优化和进一步研究.
初步研究表明,SNS对IBS中的内脏疼痛和IBD的潜在益处,可能通过抗炎途径,但临床数据有限.
临床前研究表明SNS在上部胃肠道运动障碍中的潜力,尽管没有临床试验.

结论:

圣神经刺激 (SNS) 是用于便失禁的验证治疗方法.
进一步的研究,包括方法上的进步和随机临床试验,对于确定SNS对IBS和IBD的疗效至关重要.

关键词:

自主功能是自主性的功能.功能性胃肠道疾病.炎症性肠病是一种炎症性肠病.节骨神经刺激神经刺激圣节神经调节神经调节.

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