在晚期胃癌中对卡普西塔与5-甲进行元分析
Zhongliang Wu1, Xingfa Zhang1, Chongxiang Zhang1
1Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Guizhou Medical University, Duyun, Guizhou Province, China.
概括
与5-fluorouracil相比,capecitabine改善了反应率,并减少了晚期胃癌患者的中性质衰竭和口炎. 然而,它可能会增加手脚综合征的风险,其他副作用的发病率相似.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 晚期胃癌带来了重大的治疗挑战.
- 5-甲 (5-FU) 是一种标准化疗剂.
- 卡佩奇他是5-FU的口服前药物,具有潜在的治疗优势.
研究的目的:
- 为了比较capecitabine与5-fluorouracil在晚期胃癌中的疗效和安全性.
- 评估与两种化疗相关的关键反应率和不良事件.
主要方法:
- 在主要数据库 (PubMed,Cochrane图书馆,Embase) 进行了系统的文献搜索,截至2022年6月.
- 对涉及1998名患者的8项随机对照试验 (RCT) 进行了元分析.
- 评估的结果包括整体反应率 (ORR) 和不良事件,如中性质减退,口炎和手脚综合征.
主要成果:
- 与5-FU相比,capecitabine表现出明显改善的ORR (RR 1.13,P=0.02).与5-FU相比,capecitabine表现出明显改善的ORR (RR 1.13,P=0.02).与5-FU相比,capecitabine表现出明显改善的ORR (RR 1.13,P=0.02).
- 卡佩奇他与中性质衰竭 (RR 0.78,P=0.04) 和口炎 (RR 0.73,P<0.0001) 的风险降低有关.
- 使用capecitabine观察到手脚综合征的风险增加 (RR 2.00,P = 0.007),而其他毒性是可比的.
结论:
- 凯普西他在中性病和口腔炎方面提供了更好的疗效和更有利的毒性概况,而在晚期胃癌中则提供了5-FU.
- 临床医生应考虑使用capecitabine增加手脚综合征的风险.
- 皮他是一种可行的5-FU替代品,其其他常见副作用的概况类似.
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