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在慢性心力衰竭和全身性红斑狼的共享免疫细胞和与免疫相关的共同疾病基因的识别基于转录组测序

Ziyue Luo¹, Guifang Lu², Qiang Yang¹

¹Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People's Republic of China.

Journal of inflammation research

|July 6, 2023

概括

研究人员确定了共享的免疫细胞,CD4原始的T细胞和单细胞,以及常见于心力衰竭 (HF) 和全身性红斑狼 (SLE) 的关键基因 (CCR7,RNASE2,RNASE3,CXCL10). 这些发现可能为这两种疾病提供潜在的生物标志物.

科学领域:

免疫学免疫学免疫学
遗传学是一个遗传学.
心脏病学心脏病学
类风湿病学类风湿病学

背景情况:

慢性心力衰竭 (HF) 和全身性红斑狼 (SLE) 是复杂的疾病,具有不同的病理.
了解共享的分子机制可能会揭示新的治疗点.
免疫细胞失调与HF和SLE有关.

研究的目的:

为了确定HF和SLE之间的共享免疫细胞和共同疾病基因.
探索可能的链接HF和SLE的机制.
发现两种疾病的潜在生物标志物和治疗点.

主要方法:

来自HF和SLE患者和正常对照的外周血液单核细胞 (PBMC) 的转录组测序.
差异基因表达 (DEG) 分析,免疫透分析,权重基因共同表达网络分析 (WGCNA).
蛋白与蛋白相互作用 (PPI) 分析和机器学习用于基因和细胞查.

主要成果:

CD4原始的T细胞和单细胞在HF和SLE中显示了类似的表达模式.
通过交叉免疫细胞相关基因与常见的DEGs,确定了四种与免疫相关的共同疾病基因 (CCR7,RNASE2,RNASE3,CXCL10).
在CCR7下调,而RNASE2,RNASE3和CXCL10在HF和SLE中都上调.

结论:

CD4原始的T细胞和单细胞是HF和SLE中潜在的共享免疫细胞.
确定了CCR7,RNASE2,RNASE3和CXCL10作为两种疾病共同的关键基因.
这些基因可以作为潜在的生物标志物或治疗和SLE的治疗标.

关键词:

心脏衰竭是因为心脏衰竭.免疫学免疫学免疫学机器学习是机器学习.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.转录基因组测序的转录基因组测序

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