TRIAC通过负反和器官之间异质分布来破坏脑甲状腺激素的作用
Ichiro Yamauchi1, Takuro Hakata1, Yohei Ueda1
1Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
iScience
|July 6, 2023
概括
3,3 3,3 这样就好了.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
背景情况:
- 3,3',5-triiodothyroacetic acid (TRIAC),一种甲状腺激素代谢物,已被检测到在污水下水中.
- 外源性TRIAC的内分泌干扰潜力需要调查.
研究的目的:
- 调查外源的3,3',5-三甲酸 (TRIAC) 的内分泌干扰潜力.
- 为了比较TRIAC和3,3',5-triiodo-L-thyronine (LT3) 对下丘脑-垂体-甲状腺 (HPT) 轴和小鼠基因表达的影响.
主要方法:
- 将TRIAC或LT3给甲状腺功能良好的小鼠和甲状腺功能低下的小鼠.
- 评估HPT轴活动和甲状腺激素响应基因表达在各种组织 (垂体,肝脏,心脏,大脑).
- 在血清和组织中测量TRIAC和甲状腺激素水平.
主要成果:
- 在甲状腺功能低下的小鼠中,TRIAC抑制了HPT轴,并提高了脑下垂体,肝脏和心脏中的TH反应基因的调节.
- TRIAC没有提高大脑TH反应基因的调节,其大脑含量甚至在高剂量下也没有增加.
- 在无甲状腺小鼠中,TRIAC的使用降低了血清和脑甲状腺激素水平,这表明通过负面反有效地减少了甲状腺激素水平.
结论:
- 通过抑制HPT轴和消耗内源性甲状腺激素,TRIAC会破坏内分泌系统.
- 在器官之间TRIAC的异质分布限制了它在大脑中的直接作用.
- 环境暴露于TRIAC可能会对甲状腺激素平衡产生风险.
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