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Updated: Jul 24, 2025

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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Published on: January 27, 2013

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CL-705G:一种新型化学Kir6.2特异的KATP通道开放剂

Ivan Gando1, Manuel Becerra Flores1, I-Shan Chen2

  • 1Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, United States.

Frontiers in pharmacology
|July 6, 2023
PubMed
概括

一种新型化合物CL-705G已被确定为ATP敏感 (KATP) 通道的第一个Kir6.2特定开放剂. 这种选择性开放剂显示出对治疗应用的希望,其对其他通道的交叉反应性最小.

关键词:
在KATP频道上播放.心脏保护心脏保护在 kir6.26.2 的位置上.通道开启器是一种通道开启器.结构-活动关系 (SAR)

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