一个当前和未来的观点T细胞受体谱的概况
Yiran Shen1, Alexandria Voigt1, Xuebing Leng2
1Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.
Frontiers in genetics
|July 6, 2023
概括
本综述探讨了用于分析T细胞受体 (TCR) 谱的RNA测序. 它强调了TCR基因重组的重组.
科学领域:
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- T细胞受体 (TCRs) 对于适应性免疫至关重要,通过基因重组识别抗原.
- TCRs对自我的错误处理可以驱动自身免疫性疾病.
- 了解TCR抗原相互作用是自身免疫性疾病研究的关键.
研究的目的:
- 审查RNA测序 (RNA-seq) 在研究TCR目录中的应用和进展.
- 探索转录组数据在建模TCR-抗原相互作用和预测新抗原方面的潜力.
- 讨论用于分析TCR结构和预测抗原表位的生物信息工具.
主要方法:
- 使用大量RNA测序 (RNA-seq) 进行全面的TCR谱系分析.
- 采用单细胞 (SC) RNA-seq用于高分辨率的TCR目录分析.
- 利用先进的人工智能 (AI) 工具进行结构生物学和表位预测.
主要成果:
- RNA-seq提供了对TCR曲目的定量和全面分析.
- 转录组数据有助于建模TCR-抗原相互作用和新抗原发现.
- 生物信息学和人工智能工具增强了对/TCR/MHC相互作用的研究.
结论:
- RNA-seq,特别是SC RNA-seq,是用于TCR谱系分析的强大工具.
- 将转录学与人工智能的整合为了解自身免疫和癌症免疫学提供了新的途径.
- 生物信息学工具的进一步开发将完善TCR-抗原相互作用预测和表位标识.
关键词:
哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈这是一个RNARNARNARNARNA.在TCR中,可以使用TCR.这是一种自身免疫性疾病.测序的测序是指测序的测序.更多相关视频
11:21Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
Published on: September 10, 2017
9.5K
14:14Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
Published on: December 6, 2014
16.7K
相关概念视频
Diversity of Antigen Receptors
655
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
655
T Cell Activation and Clonal Selection
832
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
832
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
