纵向变化-改变认知与皮层厚度和表面积的关联
Lars Nyberg1,2,3,4,5, Micael Andersson2,3, Anders Lundquist3,6
1Department of Radiation Sciences, Radiology, Umeå University, Umeå, Sweden.
Aging brain
|July 6, 2023
概括
大脑表面积的缩小会逐渐影响衰老中的处理速度. 皮层稀疏会在晚些时候出现,仅在晚期衰老阶段影响流体认知.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 认知能力下降 认知能力下降
背景情况:
- 已知与年龄相关的大脑体积的变化,但像表面积和厚度这样的成分研究较少.
- 对老化大脑结构和认知功能的纵向研究至关重要.
研究的目的:
- 为了研究10年内皮质表面积 (SA) 和厚度 (TH) 的与年龄相关的变化.
- 检查这些结构变化与认知功能,特别是处理速度之间的关联.
主要方法:
- 分析了从基线时55-80岁的健康个体获得的10年,3波纵向数据.
- 利用双变的潜变得分模型来评估大脑结构变化和认知变化之间的关联.
主要成果:
- 在额叶,叶和状协会皮层中观察到皮层SA的与年龄相关的显著变化.
- 皮层SA变化与5年和10年的处理速度变化有显著的关联.
- 皮质稀薄显示出晚期发病,并且仅在10年模型中与认知能力下降有关.
结论:
- 皮层表面积的减少是一种逐渐老化过程,影响信息处理能力.
- 皮质稀薄变得显著,并影响流体认知,主要是在晚年衰老.
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