老年人通过减少饮食中所摄取的棕酸摄入量来改变大脑功能和全身炎症基调
Julie A Dumas1, Janice Y Bunn2, Michael A LaMantia3
1Department of Psychiatry, Larner College of Medicine, The University of Vermont, Burlington, VT, USA.
Aging brain
|July 6, 2023
概括
在老年人中,减少食的棕酸 (PA) 和增加油酸 (OA) 降低了炎症标志物,并影响了与工作记忆相关的大脑活动. 这种饮食转变会影响老年人的细胞因子分泌和神经连接.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 在年轻人身上进行的先前研究将减少的棕酸 (PA) 和增加的油酸 (OA) 摄入量与减少的炎症和大脑活动的改变联系起来.
- 在老年人中,这种饮食脂肪酸修改的影响仍然不太清楚,特别是在认知功能和炎症反应方面.
研究的目的:
- 研究饮食减少棕酸 (PA) 和增加油酸 (OA) 对老年人工作记忆,大脑活化和细胞因子分泌的影响.
- 为了比较高PA饮食与低PA/高OA饮食在这个人口群体中的影响.
主要方法:
- 一个随机的交叉试验,涉及10名老年人 (65-75岁) 在两个1周的饮食期间 (高PA与低PA/高OA).
- 功能磁共振成像 (fMRI) 用于评估N-back工作记忆任务和休息状态连接期间的大脑激活.
- 细胞因子水平在血和由脂聚糖 (LPS) 刺激的外周血液单核细胞 (PBMC) 中测量.
主要成果:
- 在工作记忆任务期间,较低的饮食PA/较高的OA增加了右背侧前额叶皮质的大脑激活.
- 在低PA/高OA饮食期间,在突出网络的前部区域观察到增强的连接性.
- 在刺激的PBMC中,促炎性细胞因子IL-1β,IL-8和IL-6的度在低PA/高OA饮食中显著降低.
结论:
- 降低饮食中的棕酸摄入量和增加老年人中的油酸可以降低对促炎性细胞因子分泌的调节.
- 饮食脂肪酸操纵影响工作记忆基于任务的激活和老年人的休息状态功能连接.
- 这些发现表明,一种潜在的饮食策略可以调节老年人群的炎症和大脑功能.
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