艾克尔曼西亚·穆奇尼菲拉和比菲多细菌 (Bifidobacterium bifidum) 通过调节FXR表达和肠道微生物群来预防NAFLD
Fulin Nian1, Longyun Wu1, Qiaoyun Xia1
1Department of Gastroenterology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Journal of clinical and translational hepatology
|July 6, 2023
概括
阿克尔曼西亚尼菲拉和Bifidobacterium bifidum通过改善代谢健康和调节肠道微生物群来保护免受非酒精性脂肪性肝病 (NAFLD) 的影响. 这些益生菌显示出作为NAFLD新治疗策略的希望.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一个普遍存在的全球健康问题,与肠道微生物群失调有关.
- 单个细菌菌株的具体作用,如Akkermansia muciniphila和Bifidobacterium bifidum,在NAFLD病原和预防方面仍然不完全理解.
研究的目的:
- 在高脂肪饮食小鼠模型中调查Akkermansia muciniphila和Bifidobacterium bifidum对非酒精性脂肪性肝病 (NAFLD) 的预防作用.
- 探索这些细菌菌株单独或联合使用对代谢参数,肠道微生物群组成和潜在分子机制的影响.
主要方法:
- 小鼠接受高脂肪饮食 (HFD) 20周.
- 实验组接受了抗生素,其次是Akkermansia muciniphila,Bifidobacterium bifidum或PBS.
- 评估的是甘油脂代谢指标,肝脏和肠道的FXR表达,紧结蛋白,炎症状态和肠道微生物群的改变.
主要成果:
- 在HFD诱导的NAFLD小鼠中,Akkermansia muciniphila和Bifidobacterium bifidum都显著减弱了体重增加,胰岛素耐药性和肝脂沉积.
- 益生菌的使用减少了促炎因素和Th17细胞,同时增加了调节性T细胞 (Treg).
- 这些菌株调节了farnesol X受体 (FXR) 表达,并通过增加密集结蛋白表达来增强肠道屏障功能,以及有益的肠道微生物群转移.
结论:
- 阿克尔曼西亚尼菲拉和Bifidobacterium bifidum显示出对高脂肪饮食引起的非酒精性脂肪性肝病 (NAFLD) 的保护作用.
- 这些益生菌单独或协同使用,代表了NAFLD潜在的替代治疗策略,需要进一步调查.
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