免疫疗法治疗癌症患者的基线C反应蛋白水平和生存结果之间的关联:元分析
1Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Experimental and therapeutic medicine
|July 6, 2023
概括
高基线C反应蛋白 (CRP) 水平与接受免疫检查点抑制剂 (ICI) 的癌症患者的生存率较差有关. 10 mg/l或更高的CRP水平表明这些患者的预后更差.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生物标志物 生物标志物
背景情况:
- 在接受免疫检查点抑制剂 (ICI) 治疗的癌症患者中,基线C反应蛋白 (CRP) 的预后意义仍然不确定.
- 免疫检查点抑制剂已经彻底改变了癌症治疗,但预测患者的反应和生存是至关重要的.
研究的目的:
- 进行一项元分析,评估ICI治疗的癌症患者基线C反应蛋白 (CRP) 水平的预后值.
- 在接受免疫治疗的患者中,确定基线CRP水平与整体存活率 (OS) 和无进展存活率 (PFS) 之间的关联.
主要方法:
- 对队列研究进行了系统的元分析,搜索了多个电子数据库 (PubMed,EMbase等). 在2020年11月之前.
- 包括的研究重点是基线CRP水平与ICI生存结果之间的关系.
- 数据提取和质量评估是独立进行的,并使用STATA 14.0.0进行元分析.
主要成果:
- 分析包括13项队列研究,涉及2387名患者.
- 在接受ICI治疗的患者中,基线CRP水平升高与较低的OS和PFS显著相关.
- 亚组分析证实了这种关联在各种癌症类型 (例如,非小细胞肺癌,黑色素瘤,细胞癌) 和10毫克/升的CRP切断值.
结论:
- 基线C-反应蛋白水平,特别是≥10 mg/l,可以作为接受ICI的固体瘤患者的宝贵预后生物标志物.
- 较高的基线CRP水平表明死亡风险增加和生存结果较差.
- 由于目前证据的局限性,需要进一步的前性,精心设计的研究来验证这些发现.
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